李多川（Li  Duochuan, Li DC）

       Li Duochuan received a PhD in 1996 from China Agricultural University. He is  currently professor in Shandong Agricultural University. He has undertaken about  10 projects, such as NSFC, 863 program and National Key Technology Research and  Development program. He has published more than 50 peer-reviewed papers in  international journals and has been granted 4 patents.

Research  Focus

1.  Thermophilic  Fungi: Diversity, structure and function of thermostable enzymes, and adaptation  to high temperature.

2.  Pathogenic  Fungi: Pathogen  association molecular pattern (PAMP)from  Rhizoctonia  solani.

3. Acidophilic  Fungi: Diversity and adaptation to acid environment.

Selected  Publications

1.  Chen  JY, Guo XN, Zhu M, Chen C, Li DC. 2019. Polysaccharide monooxygenase  catalyzation of the oxidation of cellulose to form glucuronic acid-containing  cello-oligosaccharides. Biotechnol  Biofuels12:42.

2. Mohsin  I, Poudel N, Li DC, Papageorgiou AC. 2019. Crystal structure of a GH3  β-glucosidase from the thermophilic fungus Chaetomium  thermophilum.Int J Mol Sci 20:  5962.

3. Chen  C, Chen JY, Geng ZG, Wang MX, Liu N, Li DC. 2018. Regioselectivity  of oxidation by a polysaccharide monooxygenase from Chaetomium  thermophilum.  Biotechnol  Biofuels 11:155.  

4. Papageorgiou  AC, Chen J, Li DC. 2017. Crystal structure and biological implications of a  glycoside hydrolase family 55 β-1,3-glucanase from Chaetomium  thermophilum.  Biochimica  et Biophysica Acta-Proteins and Proteomics,1865:1030-1038.

5. Ma  YN, Han C, Chen JY, Li HY, He K, Liu AX, Li DC.2015. Fungal  cellulase is an elicitor but its enzymatic activity is not required for its  elicitor activity.  Molecular  Plant Pathology 16:14-26.

6. Papageorgiou  AC, Li DC. 2015. Expression,  purification and crystallization of a family 55 beta-1,3-glucanase  from Chaetomium  thermophilum.  Acta  Cryst F 71:680-683.

7. Xu  XX, Chen JY, Xu HJ, Li  DC. 2014. Role  of a major facilitator superfamily transporter in adaptation capacity of  Penicillium funiculosum under extreme acidic stress.  Fungal  Genet Biol 69:  75-83.

8. Teemu  H, Frioux C, Zhnag LQ, Li  DC,  Papageorgiou AC. 2014. Crystal  structure and biochemical characterization of a manganese superoxide dismutase  from Chaetomium thermophilum.  Biochimica  et Biophysica Acta-Proteins and Proteomics 1844:422-429.  

9. Wang  F, Li AN, Dai DM, Xu XX, Li  DC.  2013. A  new halotolerant species of Alternaria from  Qinghai-Tibet Plateau, China. Mycotaxon 123:251-253.

10. Wang  XJ, Peng YJ, Zhang LQ, Li AN, Li  DC.  2012. Directed evolution and structural prediction of cellobiohydrolase II from  the thermophilic fungus Chaetomium  thermophilum.  Appl  Microbiol Biotechnol 95:1469–1478.

11. Li  AN, Yu K, Liu HQ, Zhang J, Li H, LiDC. 2010.Two  novel thermostable chitinase genes from thermophilic fungi: cloning, expression  and characterization. Bioresourse  Technol 101:5546-5551.

12. Wakadkar  S,  Zhang  LQ,  Li  DC,  Haikarainen  T,  Dhavala  P,  Papageorgiou  AC.  2010. Expression, purification and crystallization of Chaetomium  thermophilum Cu/Zn  superoxide dismutase. Acta  Crystallogr Sect F Struct Biol Cryst Commun 66:1089-1092.  

Patents

1.  Li  DC，Yang  ZQ. 2020. A  mutant of exoglucanase from Myceliophthora  thermophila and  its application. China Patent, No. ZL201711226279.2.

2. Li  DC, LI AN, Han S. 2015. Yeast  engineering strain expressing a mutant of lipase from Thermomyces  lanuginusus.  China Patent, No. ZL201310204916.4.

3. Li  DC, Han C. 2015. Yeast  engineering strain expressing AA9 CtAA9d  from  Chaetomium  thermophilum.  China  Patent, No.  ZL201310422852.5.

4. Li  DC, C J. 2009. Yeast  engineering strain expressing GLA from Chaetomium  thermophilum and  its construction method. China Patent, No. ZL200610043937.2.

Books

1.  Li  DC, Papageorgiou AC. 2019.Cellulases  from Thermophilic Fungi: Recent Insights and Biotechnological  Potential.  In:  Fungi  in Extreme Environments: Ecological Role and Biotechnological  Significance (Edited  by Sonia  TA, Martin G), Springer  Publishers.

2. Li  DC. 2015. Cellulases from Thermophilic Fungi. In:Thermophilic  Microorganisms (Edited  byFL  Li). Caister Academic Press.

3. Li  DC, Li AN. 2009. Current Advances in Fungal Chitinases. In:Applied  Mycology (Edited  by Rai  M,  Bridge PD).  CABI.

E-mail:  [email protected],  Tel: 0538-8249071